Post Date December, 03 2023
The pathogenesis of chronic prostatitis syndrome? "I have always been concerned by male friends, so what are the pathogenesis of chronic prostatitis syndrome?"? Let's take a look:
1. Characteristics of modern life: Internet access, driving, sedentary office work, mental and psychological stress, personality characteristics, indulgence, and spicy and stimulating diet.
2. Infection: From the body and urethra, including bacteria, mycoplasma chlamydia, viruses, anaerobic bacteria, bacterial L-forms, gonococci, fungi, trichomonas, mycobacterium tuberculosis, and so on.
3. Abnormal urination and urine reflux: Infection, cold, emotional factors, holding urine, prolonged driving, alcohol, and stimulating food can cause excessive and frequent contraction of the smooth muscle of the prostate urethra and bladder neck, leading to bladder outlet neck obstruction, partial residual urine formation, and increased pressure in the prostate urethra, ultimately causing urine to flow back into the prostate, forming chemical prostatitis, If the pathogen is brought into the urine, it forms infectious prostatitis. Recurrent inflammation of the prostate gland and prostate urethra further causes chronic fibrosis of the smooth muscle of the bladder neck and prostate urethra, further exacerbating prostate urine reflux.
4. Chronic hyperemia of the prostate: Multiple sexual partners, indulgence, desire failure, long-term long-distance driving, cold stimulation, long-term alcoholism, and chronic infection of the urethra cause chronic hyperemia of the smooth muscle gland tissue of the prostate. This chronic hyperemia is closely related to urine reflux, dysfunction of the smooth muscle in the urinary tract of the prostate, and bladder neck.
5. Psychopsychological factors: Personality disorders, unhealthy mental health, resulting in autonomic nervous dysfunction, dysfunction of nerve receptors, dysfunction of smooth muscle of the prostate, urethra, bladder neck, spasm, causing or exacerbating abnormal urination or urinary reflux.
6. Neuroendocrine: The pain of patients with prostatitis or chronic prostatitis syndrome has its typical characteristics, that is, due to dysfunction of the nerve receptor smooth muscle of the posterior urethra of the prostate, the afferent nerves of the prostate cause spinal cord reflex, which leads to abnormal perineal and pelvic floor muscle group function and spasm, which involves the occurrence of pain.
7. Reasons for Immune and Prostate Antibacterial Factors: The prostate is the organ that contains the most zinc in the body. Prostate Antibacterial Factors (ABF) are mainly composed of active zinc. Abnormalities in zinc levels may be related to disorders in intake, loss, metabolism, and utilization of conversion mechanisms. Fluctuations in zinc levels can cause abnormalities in prostate immune function, or abnormalities in prostate and systemic immune function can cause fluctuations in prostate zinc levels. Refluxing urine or accompanying pathogens and their metabolites, as well as prostate necrosis tissue caused by chronic inflammation of the prostate, are antigenic substances that can cause immune responses, affect the immune environment of the prostate, and cause immune, sterile inflammation. Moreover, this effect may be the distribution and damage of islands. It is worth noting that clinical urologists often neglect the role of prostate immune dysfunction factors in the treatment of chronic prostatitis syndrome.
8. Pathological characteristics of chronic prostatitis syndrome:
1. The prostate is composed of many small glands, so the formation of chronic inflammation is often island type or focal type inflammatory damage. According to Professor Li Hongjun, focal type accounts for 10%, multifocal type accounts for 10-50%, and diffuse type accounts for 50%.
2. Smooth muscle lesions involve the smooth muscle of the urethra and bladder neck of the prostate, especially in patients with widespread infection, causing chronic inflammation of the smooth muscle and neuroendocrine dysfunction that governs the smooth muscle.
3. Inflammation can occur within, around, or in the stroma of the gland.
(Intern Editor: Cai Junyi)
