1. Viral infection
Herpes simplex virus type II, human papillomavirus (HPV), human cytomegalovirus, and fungal infections may be associated with the occurrence of cervical cancer. Persistent infection of high-risk HPV is the main risk factor for cervical cancer. More than 90% of cervical cancer is accompanied by high-risk HPV infection.
2. Sexual behavior and number of deliveries
Multiple sexual partners, first sexual activity<16 years old, young age at first birth, and multiple pregnancies are closely related to the occurrence of cervical cancer. The incidence rate of cervical cancer in women who have sex prematurely (meaning they have sex before the age of 18) is four times higher than that in women who have sex since the age of 18. Women who start their sexual life early and suffer from sexually transmitted diseases such as syphilis and gonorrhea are six times more likely to develop cervical cancer than normal women. It has been confirmed that if women have sexual intercourse with multiple men, their chances of developing cervical cancer are higher, while virgins are less likely to develop cervical cancer. Unmarried and nulliparous women have very little chance of suffering from cervical cancer, and the incidence rate of cervical cancer in multiple marriages is also high. Multiple deliveries with poor perinatal maintenance and delivery process can also increase the incidence of cervical cancer. However, multiple deliveries do not increase the incidence of cervical cancer.
3. Other biological factors
The infection of Chlamydia trachomatis, herpes simplex virus type II, trichomonas and other pathogens plays a synergistic role in the pathogenesis of cervical cancer caused by high-risk HPV infection.
4. Other behavioral factors
Smoking as a synergistic factor of HPV infection can increase the risk of cervical cancer. In addition, malnutrition and poor hygiene conditions can also affect the occurrence of diseases.