Post Date December, 03 2023
Because of its powerful anti-inflammatory and immunosuppressive effects, hormones play an important role in the treatment of kidney disease.
The use of hormone in kidney disease is usually long-term and high-dose. The hormones commonly used in kidney disease include prednisone, prednisolone and methylprednisolone. What should kidney friends pay attention to during the use?
1 Time of administration
The human body also has hormone secretion every day. In order to avoid over-inhibiting the physiological secretion and natural rhythm of human hormone when taking medicine, the doctor will suggest that the patient should give the hormone at one time at about 8 o'clock in the morning.
2. Side effects and precautions during administration
Long-term use of large doses of hormones may cause related side effects.
1. Water, salt, protein, fat and other metabolic disorders: cause centripetal obesity, full moon face, hairy, acne, edema, hypokalemia, elevated blood sugar, blood pressure and blood lipids;
Precautions: The "ugly" symptoms such as fat face, hairy face and acne will recover after the hormone has stopped taking medicine for a period of time. In addition to the abnormal metabolism caused by hormones, hormones also make people fat because they make people overeat and increase their appetite.
When taking medicine, patients need to review blood pressure and blood biochemistry regularly. If necessary, they may need drugs such as antihypertensive, lipid-lowering and hypoglycemic drugs. Generally, it can return to normal within a few months after drug withdrawal.
2. Infection: After taking the drug, the patient's anti-infective ability decreases. The hormone has anti-inflammatory but no antibacterial effect, so it is beneficial to the growth, reproduction and diffusion of bacteria, and it is easy to expand some originally hidden infectious foci.
Precautions: avoid pricking and pushing people, especially people with cold, after taking hormone. The infected focus of the patient should be cleaned up in time and thoroughly: focus on the areas easy to be infected, such as the mouth, ear, nose and throat, and around the anus.
3. Induce and aggravate peptic ulcer: because hormone can hinder tissue healing and repair, promote secretion of gastric acid, etc., aggravate peptic ulcer, and even cause perforation.
Precautions: Observe your stool. If you have black stool and blood, you need to inform your doctor in time.
4. Psychoneurological symptoms: excitability, excitement, insomnia. Individual patients can induce psychosis.
Precautions: It is forbidden to have psychotic tendencies and epilepsy.
5. Osteoporosis and fracture: hormones can interfere with the metabolism of calcium and phosphorus.
Precautions: Generally, preventive use of vitamin D and calcium tablets is required.
6. Severe cases may have necrosis of the femoral head: this is one of the most serious complications of hormone use.
Precautions: If there is hip joint pain and movement limitation, it is usually more obvious after the movement. Inform the doctor in time.
7. Glaucoma and cataract: can induce cataract; It can increase intraocular pressure and induce glaucoma.
Precautions: Inform the doctor in time when the eyes cannot see clearly and other symptoms occur.
3. The side effects of different drugs may be different
Prednisolone and methylprednisolone do not need to be metabolized by the liver, so they are more suitable for some patients with liver problems and will not increase the burden of the liver. Prednisone needs to be converted through liver and should be avoided in patients with liver function damage.
Although dexamethasone has strong anti-inflammatory activity, it is rarely used in clinic because of its excessive inhibition of physiological hormone axis and the increase of muscle toxicity.
4 Precautions during drug withdrawal
Because hormone has drug withdrawal reaction and rebound phenomenon, drug withdrawal needs to be very careful.
The drug withdrawal must be under the guidance of the doctor, not after the symptoms are controlled. This is also the thing that the doctor often emphasizes repeatedly with the patient.
When the hormone is used in medium or large doses for a long time, the corresponding symptoms may appear if the dose is reduced too fast or suddenly stopped. The mild cases may be manifested as mental depression, fatigue, loss of appetite, joint and muscle pain, the severe cases may appear fever, nausea, vomiting, hypotension, etc., and the severe cases may even occur suprarenal cortical crisis, which requires timely rescue.
Excessive reduction or sudden discontinuation can also cause recurrence or aggravation of the primary disease.
So again, don't stop hormone without authorization.
