Rifampicin: It is a drug enzyme inducer that can accelerate the metabolism of itself and other drugs. Taking oral contraceptives together can accelerate the metabolism of the main components of oral contraceptives, norethisterone and ethinylestradiol, and reduce the concentration of the drug in the blood; It is also possible to cause partial detachment of the endometrium, leading to bleeding or incomplete dripping, which can reduce the effectiveness of contraceptive pills and lead to contraceptive failure.
Antibiotics: 38 women who took the contraceptive pill while also taking ambroxol, neomycin, tetracycline, compound sulfamethoxazole, and chloramphenicol observed that the reason for pregnancy was due to antibiotics inhibiting the intestinal microbiota, significantly reducing the amount of glucose enzymes produced by intestinal bacteria, and affecting the absorption of contraceptive drugs in the intestine
Anti epileptic drugs: When women with epilepsy take drugs such as phenobarbital, phenytoin sodium, carbamazepine, and propafenone, it can promote the increase of drug metabolism enzymes in liver cells, accelerate the destruction of oral contraceptives, and also increase the binding of progesterone and globulin, greatly reducing the concentration of free drugs, leading to contraceptive failure. Enzyme inducers: Taking sedative and sleeping pills such as Sleeping Pill and anti rheumatic drugs such as Baotai Song can increase the metabolic activity of liver microsomal enzymes, accelerate the metabolism of oral contraceptives, and reduce contraceptive effectiveness. When sleeping pills are necessary, stable ones can be chosen.
Griseofulvin: When used in combination with contraceptive pills, griseofulvin alters the activity of enzymes in the liver, reduces solid hormones, reduces menstrual flow, and leads to contraceptive failure. It has been reported abroad that among 20 women who took the contraceptive pill, 15 had decreased menstrual blood, 5 had amenorrhea, and 2 became pregnant after starting to take griseomycin.
Medicines for treating rheumatoid arthritis, such as sedatives and sleeping pills such as Mian'ertong and Baotai Song, have enzymatic effects and can promote the metabolic activity of liver microsomal enzymes, accelerate the metabolism of oral contraceptives, and reduce contraceptive effectiveness. If sleeping pills must be used, diazepam can be used instead.
When taking contraceptive pills simultaneously, such as prednisone and dexamethasone, it can increase the function of skin hormones, but it can also delay the metabolism of corticosteroids, greatly increasing their side effects.
In summary, for women who want to use contraception, if they need to take other medications while taking the contraceptive pill, they must use the medication under the guidance of a doctor or pharmacist, and take effective measures to achieve the goal of not affecting the efficacy but also being able to use contraception.