Utilizing Micro Traditional Chinese Medicine Infiltration Therapy to Degradation Balance

Micro traditional Chinese medicine penetration therapy refers to the use of traditional Chinese medicine, starting from the source of kidney disease, mainly to expand blood vessels, improve body functions, and achieve the goal of treating kidney disease. When kidney disease progresses to a large amount of ECM deposition, uremia can form

Once kidney disease is not effectively controlled and treated in the early or inflammatory stage, damaging renal interstitial fibroblasts, interstitial fibroblasts will undergo phenotype transformation. Especially when they transform into myofibroblasts, they will release a large amount of extracellular matrix (ECM). ECM accumulates in large amounts, forming scars and replacing normal kidney structure to form uremia. At this point, treatment should focus on promoting apoptosis of myofibroblasts and regulating the balance between ECM generation and degradation.

At this point, the micro traditional Chinese medicine infiltration and exudation therapy still focuses on its powerful vasodilation, anti-inflammatory, anticoagulant, and degradation effects. Resolve to block the worsening chain of inflammation through vasodilation, anti-inflammatory, and anticoagulant effects, and to block the hope of kidney fibrosis caused by it. The inactivation results effectively inactivate the appearance activity of fibroblasts in the renal interstitium, preventing them from releasing nephrotoxic factors and transforming into myofibroblasts, promoting apoptosis of myofibroblasts. This long-lasting treatment will no longer increase the synthesis of ECM.

Due to the damage of a large number of cells, the structural achievements will also change. The generation and degradation activity of matrix metalloproteinases (MMPs) that have a degradation effect on ECM in the structure will decrease, and the ability of structural restraint factors (TIMPs) to restrain degradation will increase. Causing imbalance in the dynamic balance of MMPs/TIMPs and imbalance in the synthesis and degradation of ECM. In this regard, in addition to the effects of vasodilation, anti-inflammatory, and anticoagulation, the most important aspect of micro traditional Chinese medicine infiltration and exudation therapy is to exert the degradation effect, regulate the above two balances, and promote ECM degradation.

In the mechanism of degradation results, the tension effect of microenvironmental traditional Chinese medicine infiltration and exudation therapy is as follows: activating MMPs zymogen activator activity with active substances, promoting MMPs zymogen to generate MMPs; Suppress the generation of TIMPs, lower their activity, and suppress their inhibition of MMPs generation; Activates the prothrombin activating factor (PA) in serine proteases, promoting the production of thrombin from prothrombin. Accelerate the synthesis of MMPs; Suppress thrombin inhibitory factor (PAI) and promote the growth of PA activity; Activating plasmin to produce plasmin; Restrain the activity of plasmin inhibiting factor and accelerate the production of plasmin.

By utilizing micro traditional Chinese medicine penetration therapy, the dynamic balance of MMPs/TIMPs in the kidneys is achieved, accelerating the degradation of ECM, blocking renal fibrosis, and effectively treating uremia and alleviating symptoms.

In summary, the use of micronized traditional Chinese medicine penetration therapy can effectively modulate ECM, degrade balance, block fibroblast damage, and have a good therapeutic effect on uremia.