So far, the use of local therapies (through the skin, ointments, or aerosols) has not been very successful, but research on these drugs is still ongoing. These drugs can be applied to the skin of the penis without the need for injection or oral administration, making them very convenient to use.
A study showed that after using a ointment containing prostaglandin E2, 30% of subjects had penile erection; Aerosols made mainly of long term vasodilator - minoxidil (a drug that relaxes smooth muscle) can dilate blood vessels and help with penile erection. A small study showed that among patients with erectile dysfunction caused by spinal cord damage, 25% of patients recovered their sexual function after taking long-term compression therapy. Although its effect is not as good as using vacuum instruments or injections, the drug does not need to invade the patient's body. There are still many studies underway, and tanning lotion - Melanotan II is a promising drug. There are also studies showing that ointments with nitroglycerin as the main component are effective in 76% of erectile dysfunction patients. Nitroglycerin accelerates the production of nitrogen oxides, which can relax smooth muscle cells. However, heart disease patients should not use this drug. A study from Egypt showed that in patients with erectile dysfunction caused by various disorders, 58% of them successfully achieved penile erection after using ointment made mainly of aminophylline, isosorbide dinitrate, and ergotalkaloids; This drug is effective in 82% of erectile dysfunction patients caused by psychological disorders. In the near future, SS Dream extract will attract people's attention. It is made from nine Eastern herbal medicines. A study on premature ejaculation from South Korea showed that 89% of participants successfully had an erection, with an average duration of 11.5 minutes, but there was no control group in this experiment.