Post Date December, 03 2023
Acute nephritis, also known as acute nephritis syndrome, is a glomerular disease. In clinical practice, acute nephritis with enlarged kidneys, known as the "big white kidney," is mainly treated with targeted methods such as traditional Chinese medicine and Western medicine. If not treated in a weak country, it can easily transform into kidney failure or even uremia.
Acute glomerulonephritis, abbreviated as acute nephritis, refers to a glomerular disease characterized by hematuria, proteinuria, hypertension, edema, and decreased glomerular filtration rate in clinical practice. Therefore, it is often referred to as "acute nephritis syndrome".
Most of them are acute streptococcal postinfection glomerulonephritis, with a course of disease usually less than 1 year and a spontaneous recovery process. In clinical practice, acute nephritis usually refers to this type of disease. The kidney in acute nephritis is swollen, grayish white and smooth, hence it is also known as the "big white kidney". There may be bleeding points on the surface, with clear cortical and medullary boundaries on the section, pyramidal congestion, and a gray spotted glomerulus. Microscopic examination: Most patients with acute glomerulonephritis exhibit acute proliferative and diffuse lesions, with proliferation and swelling of glomerular endothelial cells and proliferation of mesangial cells, resulting in narrowing or even occlusion of capillary lumens. There is significant infiltration of neutrophils and monocytes in the glomerular mesangium, capillaries, and capsule, and in severe cases, coagulation occurs in the capillaries. Under electron microscopy, hump shaped deposits can be seen on the epithelial side of the glomerular basement membrane, and sometimes small subendothelial deposits can also be seen. Immunofluorescence can reveal deposits containing immunoglobulins.
Experts point out that the treatment of this disease cannot be singular. It requires both the use of drugs to control symptoms and the use of effective traditional Chinese medicine active substances to block renal fibrosis and restore normal function in patients with acute nephritis. The treatment of nephritis generally has a longer course of disease. When using medication for treatment, attention should also be paid to combining dietary therapy and physical therapy. Repair damaged kidney tissue based on the pathological changes of different acute nephritis patients. By dilating blood vessels, anti-inflammatory, anticoagulant, degrading, and thoroughly clearing immune complexes and proliferative extracellular matrix, we can improve renal microcirculation disorders and fundamentally repair the kidneys of patients with acute nephritis.
The atypical symptoms of acute nephritis in daily life are difficult to detect. When the body feels symptoms similar to this disease, the following commonly used examination methods can be used to diagnose:
1. Cytological and serological examination: Cultured from the throat or skin infection site after the onset of acute nephritis β The positive rate of hemolytic streptococci is about 30%, and those who receive penicillin treatment in the early stage are less likely to be detected. After streptococcal infection, corresponding antibodies can be produced, and precursor streptococcal infections are often confirmed through antibody testing.
2. Blood complement determination: Except for individual diseases, in the early stage of nephritis, the total complement and C3 levels in the blood significantly decreased, and returned to normal after 6-8 weeks. This regular change is a typical manifestation of this disease. The degree of decrease in blood complement is not significantly related to the mild symptoms of acute nephritis, but if hypocomplementemia persists for more than 8 weeks, the possibility of other types of nephritis should be considered, such as membranous proliferative nephritis, cryoglobulinemia, or lupus nephritis.
3. Other examinations: In some cases, circulating immune complexes and cryoglobulin can be detected during the acute phase. Usually, typical cases do not require renal biopsy, but it is difficult to differentiate from rapidly progressive nephritis; Or those who still have hypertension, persistent hypocompletemia, or renal function impairment 3 months after the disease.
Patients with acute nephritis should also pay attention to some symptoms of the disease when choosing medication treatment, which will be more targeted when choosing. The clinical manifestations of the disease mainly include proteinuria, hematuria, edema, and hypertension. Due to the strong concealment of kidney disease, the early symptoms of glomerulonephritis are not obvious and are easily overlooked. Clinical investigations have shown that patients with glomerulonephritis often lose the optimal treatment opportunity, leading to gradual progression of renal fibrosis, ultimately leading to renal failure and uremia. Routine dialysis or kidney transplantation are used to maintain life.
The treatment of acute nephritis must not take medication indiscriminately, as some drugs have significant side effects, especially hormone drugs. So in terms of selection, kidney disease patients can appropriately prefer traditional Chinese medicine preparations for conditioning. By treating and clearing the proliferative extracellular matrix, the microcirculation of the kidney is improved.
