Post Date April, 15 2023
Conditions such as excessive diet, obesity, and emotional disorders can also lead to the occurrence of chronic nephritis in patients. Some patients overeat and drink excessively, resulting in excessive fat content in the body, which can also cause abnormal emotions and endocrine functions. So patients with chronic nephritis must pay attention to dietary issues and actively seek treatment for chronic nephritis, and must not take it lightly.
However, recent studies have put forward two theories: ① mechanical stimulation injury. Because of the mechanical stimulation of glomerular endothelial cells by systemic hypertension or glomerular hypertension, the secretion and synthesis of endothelin in constricting blood vessels are increased, while the production of vasorelaxation factors in relaxing blood vessels is reduced, resulting in local vasospasm, or proliferation of glomerular mesangial cells, producing a large number of epidermal growth factors and platelet-derived growth factors, Causing hypertrophy reactions in blood vessel walls or mesangial cells. In addition, endothelial injury can also cause insulin-like growth factor to reach the mesangial area, resulting in excessive collagen production in the vascular wall and glomerular injury The microvascular network in the kidney is composed of blood vessels with a diameter of<150 microns in the renal parenchyma, and microvascular scarcity refers to the true closure of blood vessels in the later stage of hypertension, manifested as a decrease in the number of blood vessels in anatomy. At present, the role of microvascular scarcity in target organ damage in hypertension has been confirmed, and it is speculated that they also play an important role in the pathological process of hypertensive kidney damage.
The kidney plays an important role in blood pressure regulation, and it is known that kidney disease leads to hypertension through the activation of the pressor mechanism and the loss of the decompression mechanism. On the other hand, the kidney is also one of the main target organs affected by hypertension. Both systemic hypertension and glomerular capillary hypertension can directly damage the glomerulus and cause glomerular diseases. The cause of glomerular damage caused by hypertension was previously believed to be due to systemic hypertension, which directly damages the glomerulus through vasoconstriction, arteriosclerosis, thickening of glomerular arteries, glomerular ischemia or sclerosis, or increased intraglomerular pressure.
