Many patients with nephrotic syndrome know that they should not smoke, but few can control it. Here is a reminder to patients who cannot control their smoking habit, at least not to smoke during medication. Numerous medical studies have shown that smoking during medication can affect the metabolism of nephrotic syndrome drugs, affect their effectiveness, and even delay the condition.
The nicotine contained in cigarettes, upon entering the human body, can have an impact on the metabolic enzyme system in the liver, accelerating or slowing down the process of drug metabolism, leading to a decrease in the effective concentration of drugs in the blood and inability to exert their intended effects. Nicotine can release antidiuretic hormone, which prevents the timely excretion of metabolic products in patients with nephrotic syndrome, leading to drug accumulation and poisoning. In addition, smoking can cause excessive depletion of minerals and various essential nutrients required for synthesizing vitamin C, vitamin B6, and vitamin B12, indirectly affecting the drug treatment process.
Not all medications are significantly affected by smoking. Medical research shows that drugs whose efficacy is obviously affected by smoking include antipyretic analgesics, anesthetics, antiasthmatic drugs, anti angina drugs, antiplatelet drugs, lipid-lowering drugs, hypoglycemic drugs, diuretics for patients with nephrotic syndrome, antacids, gastric mucosa protective drugs, contraceptives, etc. The common ones are theophylline, caffeine, propranolol, antipyrine, imipramine, phenacetin, analgesine, propoxyphene, furosemide, etc.
So remind patients with nephrotic syndrome to be extra careful during medication. Especially for those patients with diabetes nephropathy, smoking has a great impact on the incidence rate and treatment effect. Patients should not smoke within 30 minutes of taking oral medication. If this time cannot be controlled, the blood drug concentration will decrease to 1/20 of that of non-smokers, leading to the inability of the drug to function properly.