Recently, the Journal of the American Association of Nephrology (JASN) published online the results of a nationwide epidemiological survey of renal pathological type change and air pollution carried out by the academician Hou Fanfan team of the Southern Hospital of the Southern Medical University of China, covering 282 cities and 938 hospitals in China, with a total number of 71151 people, covering the period from 2004 to 2014.
This study retrospectively analyzed the changes of glomerular disease types in the past 11 years. IgA nephropathy is still the most common pathological type of renal biopsy and glomerular disease (28.1%), and the second has become membranous nephropathy (23.4%). After statistical correction, it is found that membranous nephropathy is growing at an annual rate of 13% in the past 11 years, and the rate is fast, and has a trend to exceed IgA nephropathy.
According to the research and analysis of membranous nephropathy in various provinces, the incidence of membranous nephropathy is higher in northern areas, especially in Hebei Province.
As we all know, Hebei Province is currently one of the provinces with the most serious air pollution in China, so the researchers put forward the hypothesis that whether long-term air pollution exposure has a certain relationship with the increase of membranous kidney disease. Then the researchers found through the nationwide 3-year average PM2.5 distribution published in recent years, as well as the national air quality index and other air pollution indicators in recent 3 years: after adjusting for age, sex After geographical and clinical factors, more PM2.5 exposure is associated with the risk of membranous nephropathy, and this relationship is nonlinear. In areas with PM2.5>70 ug/m3, the risk of membranous nephropathy will increase by 14% for every 10 ug/m3 increase in PM2.5.