Post Date December, 02 2023
Microscopic examination revealed pseudohyphae and oval spores, and fungal culture identified the genus Candida. All patients did not take systemic antifungal drugs within one month before medication, or did not use other topical antifungal drugs within two weeks. A total of 60 patients, aged 21-67 years, completed the treatment; The disease lasts from 3 days to 4 years. Among them, 24 cases were complicated with bacterial infections, 38 cases had candidal vulvovaginitis in their spouses, 49 cases had varying degrees of foreskin elongation, and 8 cases also suffered from other sexually transmitted diseases. All patients have a history of sexual activity.
The treatment method is to apply Pevison cream externally, once a day in the morning and once a day in the evening. One week is one course of treatment, totaling two courses. Follow up once a week.
Curative evaluation criteria for recovery: the rash completely subsides, the symptoms disappear voluntarily, and the fungal test is negative; Significant effect: The rash has subsided by more than 60%, the symptoms have significantly improved, and the fungal test is negative; to become better; The rash has subsided by 20% to 60%, the symptoms have improved consciously, and the fungal test is negative or positive; Invalid; The rash has subsided by less than 20% or worsened, and the symptoms have not significantly improved or worsened. The fungal test is positive. The total effective rate is recovery plus significant effect.
After 2-5 days of medication, most patients have significantly improved their symptoms and skin lesions; The clinical cure rate after one week of medication has reached 81.7%, and the effective rate is 93.3%; After the course of treatment, the clinical cure rate reached 88.3%, the effective rate was 95.0%, and 1 out of 60 cases was ineffective.
Most patients have good tolerance to this drug for adverse reactions, with only 2 patients experiencing mild local redness and swelling on the 2nd and 7th days after medication, which spontaneously relieved after discontinuation. The incidence of side effects was 3.3%.
Recurrence rate: A follow-up of 53 cured cases was conducted for 2-6 months, and a total of 16 cases were found to recur. Among them, 12 cases recurred after sexual activity, but the possibility of reinfection cannot be ruled out.
Candidal balanoposthitis has gradually increased in recent years, and it is often accompanied by bacterial infections. The effective ingredients of Pairuisong Cream are econazole nitrate and triamcinolone acetonide. Among them, econazole nitrate is an imidazole derivative that not only has broad-spectrum antifungal effects, but also has good antibacterial effects on gram-positive bacteria; Triamcinolone acetonide is a moderately potent corticosteroid with anti-inflammatory, anti allergic, and antipruritic effects, which can quickly and effectively alleviate skin symptoms. The combination of the two can reduce inflammation and itching in fungal lesions, have a synergistic effect, and improve the therapeutic effect.
