Sexual Health
Can endocrine therapy be used for sexual dysfunction? Precautions for treatment of sexual dysfunction
The endocrine therapy of male sexual dysfunction mainly refers to the application of testosterone and chorionic gonadotropin. As early as the beginning of this century, testosterone was named as the "male hormone", which is the drug for rejuvenation. Today, this understanding has already been corrected. The role of testosterone has been described in the composition and function of reproductive organs, and will not be repeated here.
It is still widely used in the treatment of male sexual dysfunction. In theory, this drug should be effective for patients with male androgen deficiency and sexual dysfunction, and many patients also reflect its subjective efficacy. However, some scholars believe that for patients with non-androgen deficiency, the drug only acts as psychotherapy and may be effective in the short term. This involves the selection of cases.
In view of the fact that such patients have low sexual endocrine potential (that is, impaired sexual endocrine reserve function), which is quite common, in fact, the scope of application of this drug is wider than expected. All patients with suspected sexual endocrine deficiency can try it, but it is not suitable for long-term use, generally 1-2 weeks. The fundamental solution is to restore the function of testicular interstitial cells or pituitary gonadotropin, otherwise the effect of drugs is temporary after all. Testosterone propionate is injected 25 mg daily for 2 weeks, or 50 mg daily for 1 week. For example, oral methyltestosterone, due to the rapid metabolism of liver after absorption, leads to a short half-life of drugs in the blood, which can be contained under the tongue, so that some drugs can be absorbed by the oral mucosa and directly enter the systemic circulation. Clinical observation suggests that this method is also desirable. 10 mg twice a day.
It should be pointed out that the abuse of male hormones is relatively common at present, especially at the grass-roots level, mainly manifested in long-term continuous use. It must be recognized that long-term abuse of testosterone can cause serious damage. The high level of testosterone reduces the secretion of gonadotropin in the pituitary gland, which can lead to testicular atrophy. A large number of experimental data show that sperm deficiency can occur within 3 months after testosterone propionate injection of 25 mg per day and continuous injection of 25 mg~; Large dose of testosterone can increase the total number of rose red blood cells, sodium and water retention; In addition, testosterone can cause serum β- Lipoprotein increased, α- The decrease of lipoproteins may be related to atherosclerosis; In some cases, testosterone also increases serum cholesterol. In addition, there are adverse reactions such as acne, hirsutism, obesity, heart and liver function damage. Animal experiments show that excessive testosterone can cause hypertension in rats.