Post Date December, 03 2023
Why is "premature death" targeted at a man in his forties? The reason is that after the age of 40, male hormone levels in the body decrease, physiological functions decline, various diseases thrive, and life killers also take advantage of the situation!
Interview expert: Professor Jin Baofang, Director of the Institute of Andrology at Nanjing University of Traditional Chinese Medicine
Androgens have a wide range of jurisdiction
Case study: Mr. Liang, 40 years old, a senior executive of a company, feels that his work efficiency has significantly decreased in the past six months, and his physical strength and memory are far from what they used to be. His wife reported that he used to have a mild personality, but now his emotions have become capricious, often getting angry about small things, and the frequency and quality of his married life have significantly decreased compared to before.
After consultation with a male doctor, it was found that the patient has been under high work pressure in the past six months, with minimal exercise and weight gain. Further examination revealed that blood sugar and blood lipids were on the high side, and serum testosterone levels were significantly reduced. The initial consideration is "male delayed hypogonadism".
Androgens, mainly composed of ketones. In addition to reproduction and urinary tract, there are androgen receptors in the skin, bones, muscles, hematopoiesis, cardiovascular system, and nervous system. That is to say, it not only promotes the development of reproductive organs, but also affects multiple systems and organs throughout the body.
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Therefore, if androgen deficiency occurs, it can cause many systemic symptoms
Neurological system: hot flashes, chest tightness, shortness of breath, palpitations, restlessness, dizziness, swelling of the brain, blackening of the eyes, insomnia, and a series of symptoms mainly characterized by autonomic nervous system dysfunction.
There are also symptoms such as decreased brain power, slow thinking, decreased memory, and decreased attention.
Mental and psychological symptoms: often feeling powerless, under high psychological pressure, lacking interest and fun in anything, feeling melancholic and pessimistic, and feeling depressed.
Likes to lose temper, constantly or intermittently anxious and nervous, restless, restless, and panicked without any reason.
Sensitive, distrustful of others, thoughtful, troublemaking, and suspicious.
Physical symptoms: limb fatigue, muscle soreness, muscle loss, increased fat, decreased libido, erectile dysfunction, etc.
Because androgens also protect cardiovascular, immune, and other systems, when their levels "decline," they can lead to a chain of health crises.
Two solo voices "Death Quartet"
Case: There is a gentleman who is 40 years old, not tall, weighs 90 kilograms, and usually has hypertension. I have been feeling lethargic and drowsy lately. The examination found that fasting blood sugar was as high as 18mmol/L, and blood lipids were also very high. The doctor joked that your 'Death Quartet' has already begun.
Hypertension, diabetes, dyslipidemia and obesity, any three of which occur at the same time, become metabolic syndrome, which is known as the "death quartet" because of its high mortality rate, such as heart and brain accidents.
And research has found that low levels of androgens are independent factors that trigger the 'quartet'.
Lipids: Androgens can activate the activity of various enzymes. Some of these enzymes help transport free fatty acids from the liver to surrounding tissues; Some can promote the oxidation of free fatty acids and reduce cholesterol synthesis.
Hypertension: Recent research has found that androgens are involved in the occurrence and development of hypertension, and may be an independent risk factor for the onset of hypertension; Comparative studies have found that the total testosterone (androgen) concentration in hypertensive patients is significantly lower than that in the normal control group, with significant differences. Therefore, it is proposed that plasma ketone levels can serve as a new indicator for evaluating risk factors for hypertension.
Obesity: Androgens have the effect of promoting protein synthesis, skeletal muscle growth, muscle development, and inhibiting the increase of body fat. When the levels of androgens decrease, men may experience a decrease in muscle mass and strength, as well as visceral fat accumulation and obesity.
Blood sugar: Muscles are the largest "sugar bank" for storing blood sugar. When muscle mass decreases, the area of the sugar bank shrinks, resulting in more glucose being trapped in the blood.
British experts found that there are 1.5 million male patients with diabetes in the UK, 40% of whom have low androgen levels.
A survey conducted by the University of California in the United States on 800 men over the age of 50 found that the mortality rate from heart disease is related to low androgen levels.
Many celebrities die around the age of 40 due to complex causes, with low levels of androgens likely playing a contributing role.
Writers Liang Zuo and Wang Xiaobo both died of sudden myocardial infarction in their 40s.
What is the relationship between androgens and myocardial infarction?
Myocardial infarction is generally caused by coronary atherosclerosis; It may also be the result of coronary artery spasm.
Androgens can increase the release of nitric oxide (NO) from vascular endothelial cells, which can relax coronary arteries, alleviate angina symptoms, improve myocardial ischemia, and alleviate coronary artery spasm.
Furthermore, the interaction between androgens and potassium channels on the cell membrane can cause changes in potassium ion flow and significantly dilate the coronary artery.
Entrepreneur Wang Junyao died of colon cancer at the age of 38; Actor Fu Biao died of liver cancer at the age of 42.
What is the relationship between androgens and cancer?
Androgens can accelerate the synthesis of various proteins in the body, including promoting the synthesis of immunoglobulins, enhancing the body's immune system, and thus promoting muscle development and physical fitness.
Androgens can also enhance the hematopoietic function of the male body's bones, allowing the bone marrow to generate more red blood cells.
If the level of androgens is low, it directly reduces a person's immune system.
After the age of 40, the blood vessels around the heart gradually harden, leading to narrowing of the lumen and a decrease in local blood oxygen supply, which directly affects organs such as the heart, brain, kidneys, and eyes.
In their thirties, androgens begin to decrease; At the age of 40, there is a significant decrease in production; At the age of 50, androgen levels are only half that of those before the age of 30; By the age of 70, androgen levels are only 10% of what they were when they were young.
Due to a significant decrease in production, men's body function will decline after the age of 40, leading to a series of adverse physical and mental reactions, commonly known as "male 40 syndrome"; Medicine refers to it as "delayed hypogonadism".
The decrease in male sexual hormone levels is slower than that of women, and most men can adapt to this change. However, more than 40% of middle-aged and elderly men still suffer from this condition.
And then there is the lifestyle:
Sitting for a long time, staying up late for a long time, and exercising less are the three major risk factors affecting testosterone, which can lead to early androgen deficiency.
Sitting still for a long time:
Sitting for a long time can compress the reproductive system, causing the prostate and * * to remain congested for a long time, increasing * * temperature. And 95% of androgens are secreted by * *.
Sitting for a long time can also lead to accumulation of abdominal fat, leading to obesity. Excessive obesity can lead to a decrease in male androgens and a relative increase in estrogen levels. The increase in estrogen levels in turn counteracts the effects of androgens, forming a vicious cycle.
Frequent staying up late:
At night, the endocrine hormones in the human body decrease. If you stay up late for a long time, it will stimulate the excitement of the cerebral cortex and force it to continue to secrete too much hormone, which will destroy the normal hormone secretion in men over time, resulting in the lack of androgen.
Tobacco and alcohol content:
The toxic substances in smoke can damage the stromal cells specialized in producing androgens.
Under alcohol stimulation, androgens are broken down by the liver and converted into other substances.
More and more young people are experiencing androgen deficiency in outpatient clinics. The normal androgen level is 9-40, while many college students have androgen levels of 9-10, which are already on the brink of deficiency.
And middle-aged elite elites often work overtime and stay up late. Moreover, there are inevitable social interactions, such as eating sea food recklessly and indulging in excessive smoking and drinking. Therefore, when people reach their forties, the level of androgen decline is often more severe than normal, and even leads some people to the "hero's end".
Over 40 years in 5 years, the body needs major repairs
I have eaten a lot of kidney tonifying and yang enhancing foods, but why are my androgen levels still so low
Many people believe that tonifying can improve the symptoms of "40 syndrome". In fact, kidney tonifying and yang strengthening drugs can only act on the endocrine system and are not the same concept as increased secretion of androgens.
If the exogenous androgen is not replenished properly, it is likely to interfere with normal endocrine function.
The hypothalamic pituitary gonadal axis affects the balance of endocrine system. Excessive androgen supplementation can inhibit the function of the hypothalamus and pituitary gland, leading to functional failure, inhibition of sperm production, and infertility.
Excessive supplementation can also lead to impulsiveness, irritability, hyperthyroidism, hair loss, and more.
The danger is that it can cause acute myocardial infarction and stroke, as testosterone can regulate the expression of TXA2 receptors in platelets and blood vessels. Abuse of androgens can significantly increase the aggregation reaction of platelets, leading to thrombotic diseases.
Even more dangerous is the possibility of cancer. Because the growth of male prostate cells is regulated by male hormones. During the period from youth to middle age, the proliferation and apoptosis of prostate cells are in a relatively balanced state. After entering middle age, the rate of proliferation exceeds the rate of apoptosis. At this time, blindly and excessively supplementing exogenous male hormones for a long time may promote prostate hyperplasia and even increase the risk of prostate cancer.
However, experts say that for certain populations, it is still necessary to supplement androgens appropriately. In 2010, the consumption of exogenous androgen drugs in the United States was $700 million, while in China it was only RMB 30 million.
The supplementation of exogenous androgens has strict indications and must be used under the guidance of a professional physician, and regular clinical observation is required.
The best way for men to exercise is:
Exercise muscles. The biggest characteristic of human muscles is that 'when used, it grows; when not used, it recedes'. And muscles are the primary foundation for ensuring male hormones; Another step is to adjust one's lifestyle.
If you are over forty years old and there are no other changes in your body, but there are four phenomena: decreased sexual function, decreased energy and energy, significant decline in physical fitness, hot flashes, and sweating, it is important to pay attention!
